Abstract: For wideband Multiple Input And Multiple Output (MIMO) and orthogonal frequency division multiplexing (OFDM) wireless system, the fading selectivity in spatial-temporal-frequency domain and the variable network load and interference put a constraint on the system design. The traditional layered protocol design canpsilat adapt to these variance and results in low transmission efficiency. In this paper, a cross layer framework for multiuser radio resource management (RRM) in MIMO and OFDM system is proposed to optimise the system performance. Based on this, two cross layer scheduling algorithms based on Modified Proportional Fairness (MPF) and Quality Guaranteed (QG) priority function are designed for mixed Real Time (RT) and Non-Real Time (NRT) services in multiuser MIMO OFDM system. From the simulation results, QG&MPF has much better performance than M2PF. For 2times4 MIMO case, QG&MPF can support 40 RT user and 40 NRT users in 10 MHz bandwidth simultaneously, and the system throughput of QG&MPF can approach 32 Mbps; while M2PF can only support 15 RT users and 15 NRT users, and the system throughput is about 11.5 Mbps.